Preliminary coronary research suggests that thirdhand smoke may be associated with heart disease.

Exposure increases lipid levels, inflammatory cytokine production, and collagen stimulation in animals, all of which potentially contribute to cardiovascular disease. Recent human hematology research links thirdhand smoke exposure to elevated levels of triglycerides and coronary thrombosis, which increase the risk of heart attack and stroke.

Karim, Z. A., Alshbool, F. Z., Vemana, H. P., Adhami, N., Dhall, S., Espinosa, E. V., Martins-Green, M., & Khasawneh, F. T. (2015). Third-hand smoke:
Impact on hemostasis and thrombogenesis. Journal of Cardiovascular Pharmacology, 66(2), 177–182. https://doi.org/10.1097/fjc.0000000000000260

Roy, A., Rawal, I., Jabbour, S., & Prabhakaran, D. (2017). Tobacco and Cardiovascular Disease: A Summary of Evidence. In Cardiovascular, respiratory, and related disorders. 3rd edition. The World Bank Group. https://www.ncbi.nlm.nih.gov/books/NBK525170/

Martins-Green, M., Adhami, N., Frankos, M., Valdez, M., Goodwin, B., Lyubovitsky, J., Dhall, S., Garcia, M., Egiebor, I., Martinez, B., Green, H. W., Havel, C., Yu, L., Liles, S., Matt, G., Destaillats, H., Sleiman, M., Gundel, L. A., Benowitz, N., … Curras-Collazo, M. (2014). Cigarette smoke toxins deposited on surfaces: Implications for human health. PLoS ONE, 9(1). https://doi.org/10.1371/journal.pone.0086391